Trichostatin A stabilizes the expression of pluripotent genes in human mesenchymal stem cells during ex vivo expansion.
BACKGROUND: Mesenchymal stem cells (MSCs) have been considered as ideal cells for the treatment of a variety of diseases.However, aging and spontaneous differentiation of MSCs during culture expansion dampen their effectiveness.Previous studies Dishwasher ComfortLift Hinge suggest that ex vivo aging of MSCs is largely caused by epigenetic changes p